Compound Report Card

However, periodic monitoring of blood pressure, particularly during the first few days after administration, is advised. We do not believe that severe hypertension was contributory to her heart failure since it was transient and she was normotensive in the period preceding her decompensation. Furthermore, presentation of neurogenic stunned myocardium typically mimics acute myocardial infarction and manifests as Takotsubo cardiomyopathy, whereas our patient had no evidence of ECG abnormalities or apical ballooning to corroborate this.

  • Her social skills (per the Achenbach Child Behavior Checklist [CBCL] score) were similar to those of children of her age.
  • He began replacement therapy (levothyroxine and testosterone) and cabergoline 500mg twice weekly with full counselling.
  • These losses could be due to the prolactin inhibitory properties of cabergoline in rats.
  • There was severe hypokinesia of the posterior wall and apical segments.
  • Off cabergoline, his prolactin rose to 5460mU/l so it was resumed at 250mg weekly with close monitoring.

We advised the patient to reduce her mental stress and planned to perform IUI after additional ovulation induction. After the induction of artificial cycles, gonadotropin-releasing hormone agonist (GnRHa; triptorelin) was given on day 25 of the menstrual cycle (0.1 mg, subcutaneous injection, for 18 days). Hormone tests returned a serum E2 level of 9.14 pg/mL, an LH level of 0.52 mIU/mL, a P level of 0.98 ng/mL, and a PRL level of 115.2 ng/mL. Hormone tests returned a serum E2 level of 2,568 pg/mL, an LH level of 0.58 mIU/mL, a P level of 1.71 ng/mL, and a PRL level of 171.2 ng/mL.

Averting catastrophe: cabergoline and the clinical nurse specialist

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. Cabergoline is also sometimes used to prevent or stop milk production for medical reasons following childbirth, stillbirth or abortion. These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species.

Inhibition of lactation

Before cabergoline administration, pregnancy should be excluded and after treatment pregnancy should be prevented for at least one month. Macrolide-type antibiotics such as erythromycin may possibly increase the concentration of cabergoline in the blood, which may increase the risk of its side effects. However, small amounts of erythromycin applied to the skin can be used safely. This medicine is not recommended for use in combination with other ergot alkaloid derivatives, such as pergolide, bromocriptine, lisuride, ergotamine, dihydroergotamine, methysergide or ergometrine. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.

For the patient, her menstrual cycle resumed at month seven after birth. At the time, her menstrual cycle was 30 to 40 days, with moderate flow. She did not use birth control methods nor did she become pregnant during the four-year follow-up period. A 35-year follow-up study showed that for hyperprolactinemia patients, treatment was highly effective in 20.8% (10/48) of the patients and effective in 68.8% (33/48) of the patients.

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